Cryo-EM structure of LRP2 at pH 7.5
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8em4
Q-score: 0.36
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821- [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
- 2-acetamido-2-deoxy-beta-d-galactopyranose (221 Da, Ligand)
- Lrp2 at neutral ph (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Low-density lipoprotein receptor-related protein 2 (519 kDa, Protein from house mouse)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Local refinement map of LRP2 P1-P2 domains at pH 7.5
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
Local refinement of P3-P6 domains of LRP2 at pH 7.5
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
Local refinement of the P7 domain of LRP2 at pH 7.5
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
Local refinement of the R4 domain of LRP2 at pH 7.5
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
Local refinement of P8 domain of LRP2 at pH 7.5
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
Local refinement of P1-P2 domains of LRP2 at pH 5.2
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
Local refinement of P3-P6 domains of LRP2 at pH 5.2
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]